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KMID : 1123920180320040247
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Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 4 p.247 ~ p.254
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Antidepressant effects of Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai via Inhibition of 5-HT6 Receptor-mediated cyclic AMP Activity
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Oh Kyo-Nyeo
Oh Dool-Ri
Jung Myung-A
Kim Yu-Jin
Choi Eun-Jin
Hong Ji-Ae
Kim Jae-Yong
Choi Chul-Yung
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Abstract
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A This study evaluated the antidepressant effects of the herbal mixture CPAE(Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai) using several tests, including a test for serotonin 6(5-HT6) receptor activity, the forced swimming test(FST), and tests for corticosterone(CORT) and monoamine levels. CPAE showed antagonistic effects on the 5-HT6 receptor in a stable 5-HT6 receptor?expressing cell line. We subsequently confirmed the antidepressant effects of CPAE in chronic stress model in mice and explored the underlying mechanisms of its action. Specifically, we observed that CPAE treatment significantly reduced immobility time in the FST and effectively restored abnormal levels of CORT in plasma and of monoamines(serotonin, dopamine, and norepinephrine) in hippocampus and prefrontal cortex. These results suggest that CPAE has significant antidepressant effects.
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KEYWORD
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Cynanchum wilfordii Hemsley, Phlomis umbrosa Turczaninow, Angelica gigas Nakai, Antidepressant, 5-HT6 receptor
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